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Review Questions
Why is protein aggregation generally avoided by cells? What makes prions different from other infectious particles? What is the stress response? What is the function of Hsp104 following severe stresses? How does this function also assist with propagating prions? Are chaperones also required for a protein to acquire the prion conformation?
How was [PSI+] determined not to result from a classical genetic mutation? What happens to Sup35’s activity in the prion state? Does the ability of a protein to form a prion come from a localized region of the polypeptide sequence, or is it instead a property distributed throughout the sequence? What is the physical nature of the prion conformation?
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