Papers for Journal Club

Burleigh, B.A. and Andrews, N.W.  The mechanism of Trypanosoma cruzi Invasion of Mammalian Cells. Annu Rev Microbiol. 1995.  49:175-200.

This review specifically address the invasion mechanism used by T. cruzi to get inside host cells.  They discuss some of the different molecules that are involved in the cell invasion process.

Reddy, A., Caler, E.V., and Andrews, N.W.  Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes.  Cell.  2001.  106(2):157-169.

This paper talks about plasma membrane repair and the involvement of Ca(2+).  It also talks about synaptotagmin VII and its role in membrane repair.  It also discusses the role of lysosomes in plasma membrane repair.

Andrade, L.O., and Andrews, N.W.  Lysosomal fusion is essential for the retention of Trypanosoma cruzi inside host cells.  J Exp Med.  2004.  200(9):1135-1143.

This is the paper where the Andrews lab shows that in order for T. cruzi to be retained within the cell, lysosomal fusion is necessary.  They discuss some aspects of intracellular survival of pathogens.

Huynh, C., Sacks, D.L., and Andrews, N.W.  A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes.  J Exp Med.  2006.  203(10):2363-2375.

This is the paper where the Andrews lab showed the existence of LIT1 and its involvement in parasite survival in macrophages.  LIT1 is characterized and they show that some Leishmania species can persist in mice even when they lack the ability to grow within macrophages.  They talk of the role of iron acquisition in relation to virulence.

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