Review Questions
  1. Where in the body can you find immature dendritic cells (DC)? Mature dendritic cells?

  2. Both DC and macrophages respond to the same microbial ligands. How do they differ?

  3. What is the optimal pH at which lysosomal proteases function? What is the pH of an immature DC’s lysosome? Mature?

  4. Following synthesis in the ER, where does MHC II go? How does it get there?

  5. What lysosomal inhibitor regulates invariant chain cleavage?

  6. MHC II is localized to lysosomes in immature DCs, but is found on the cell surface in mature DCs. How is this trafficking regulated?

  7. The body produces many different types of T cells, each specialized for a particular type of response. How do DCs direct T cell responses?

  8. Which subset of T cells maintains tolerance in adults?
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