Review Questions
Q. What pathways regulate aging in C. elegans? Q. What kinds of sensory system mutations affect aging in C. elegans?
Q. What is required for sensory system mutants to live long? Q. What does laser ablation of the germ cell precursors do to lifespan in C. elegans? What does laser ablation of the somatic gonad precursors as well as the germ line do to lifespan? Q. What signaling pathway is required for the extended lifespan of animals lacking a germ line? Q. Which diseases have been shown to be regulated by the insulin/IGF-1 pathway in model organisms?
Q. What happens in the gld-1 mutant that mimics a tumor model? Q. How does the gld-1 mutation cause tumors?
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